Adverse effects of Cyclosporine

Cyclosporine is an immunosuppressant drug widely used in post-allogeneic organ transplants such as kidney, liver or heart to reduce the activity of the patient's immune system.

Cyclosporine is a conventionally used medicine for autoimmune diseases such as Psoriasis, Rheumatoid arthritis, Crohn's disease, Nephrotic Syndrome, etc.where the patient does not respond to the treatment with corticosteroids or methotrexate.

Cyclosporine is a very good immune-suppressive medicine but makes the patient susceptible to infection including cancer such as lymphoma.

The adverse effects could be listed as:

Adverse effects, which require immediate medical help (alarming signs), are:

• Hypertension: Above 50% of patients taking cyclosporine develops high blood pressure. A known case of hypertension has a risk of developing heart disease.
• Kidney Dysfunction: Scanty urine presenting as decreased frequency of urination or no urine at all.
• The risk of both these problems increases with higher doses and longer treatment with cyclosporine.
• Allergic reactions present as hives, swelling of the face lips, and throat or difficulty in breathing.
• Seizure (convulsion)
• Tachycardia (fast heart rate), muscle weakness or pain
• Flu-like symptoms as fever chills and sore throat
• Jaundice presenting as yellowing of skin and sclera, dark urine, nausea, clay-colored stools.
• Drowsiness, confusion and mood changes
• Easy bruising and bleeding
• Swelling and weight gain
• gum disease or overgrowth

Less serious side effects include:

• Abnormal Hair Growth: Both men and women may develop hair growth in abnormal amounts on the face, chest, and arms.
• Nausea and diarrhea
• Tremor: Above 50 % people develop tremors characterized by shaking. Leg cramps or muscle contractions might also be experienced.

Special precautions before starting cyclosporine:

• A person suffering from any kidney disease, uncontrolled hypertension or cancer are not eligible to take this drug.
• Psoriasis patients who have had certain previous treatments like PUVA, UVB, coal tar, radiation therapy, methotrexate, etc are at higher risk to develop skin cancer.
• Any "live" vaccine taken while you are being treated with cyclosporine will not be effective.
• There are many other medicines like vitamins, minerals, etc. which can cause serious medical problems if you take them together with cyclosporine.
• Do not start using any new medication without informing your doctor. The safest way is to keep a list of all the medicines you use and show this list to the doctor.
• Avoid eating grapefruit or drinking grapefruit juice.

Adverse effects of Cyclophosphamide, Adverse effects of Cortisone, Adverse effects of methotrexate

Written & Approved by-

Dr. Rajesh Shah

M.D. (Hom.)